The Most Valuable 2021 Panini Classics Football Cards

Ranked by real closed-sale prices across 3,836 tracked 2021 Panini Classics Football items — not guesses, not asking prices. Updated August 2026; the order shifts as the market does. Right now the crown belongs to Tom Brady [Premium Edition Significant Signature Orange] #22 2021 Panini Classics Football at $2,725.

On a budget: under $20 · under $50 · under $100

1. 1
   
   Tom Brady [Premium Edition Significant Signature Orange] #22 2021 Panini Classics Football

   $2,725· $2,725 new/sealed
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2. 2
   
   Ja'Marr Chase [Premium Edition Significant Signature] #157 2021 Panini Classics Football

   $1,000
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3. 3
   
   Trevor Lawrence [Premium Edition Significant Signature Orange] #151 2021 Panini Classics Football

   $802.13· $802.13 new/sealed
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4. 4
   
   Christian McCaffrey [Premium Edition Significant Signature Orange] #17 2021 Panini Classics Football

   $716.36· $716.36 new/sealed
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5. 5
   
   Zach Wilson [Premium Edition Significant Signature Purple] #152 2021 Panini Classics Football

   $700· $195 new/sealed
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6. 6
   
   Kyler Murray [Premium Edition Significant Signature Orange] #75 2021 Panini Classics Football

   $599.99
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7. 7
   
   Mac Jones [Premium Edition Significant Signature Orange] #156 2021 Panini Classics Football

   $549.99
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8. 8
   
   Davis Mills [Timeless Tributes Black] #172 2021 Panini Classics Football

   $507.96
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9. 9
   
   Joe Burrow [Premium Edition Significant Signature Gold] #29 2021 Panini Classics Football

   $488.46
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10. 10
    
    Josh Allen [Premium Edition Significant Signature Gold] #63 2021 Panini Classics Football

    $460· $510 new/sealed
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11. 11
    
    Justin Fields [Premium Edition Significant Signature Gold] #154 2021 Panini Classics Football

    $453.31· $500 new/sealed
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12. 12
    
    Joe Burrow [Premium Edition Significant Signature Orange] #29 2021 Panini Classics Football

    $449
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13. 13
    
    Micah Parsons [Blue Back] #196 2021 Panini Classics Football

    $442.5· $24 new/sealed
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14. 14
    
    Mac Jones [No Name] #156 2021 Panini Classics Football

    $400· $121.5 new/sealed
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15. 15
    
    Trevor Lawrence [Premium Edition Timeless Tributes Blue] #151 2021 Panini Classics Football

    $399.99
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16. 16
    
    Peyton Manning [Premium Edition Significant Signature Gold] #114 2021 Panini Classics Football

    $350· $500 new/sealed
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17. 17
    
    Tom Brady [Timeless Tributes Orange] #22 2021 Panini Classics Football

    $350· $359.99 new/sealed
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18. 18
    
    Josh Allen [Premium Edition Significant Signature Orange] #63 2021 Panini Classics Football

    $324.53
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19. 19
    
    Justin Fields [Premium Edition Significant Signature Blue] #154 2021 Panini Classics Football

    $307.81· $140 new/sealed
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20. 20
    
    Jerry Rice [Premium Edition Significant Signature Gold] #113 2021 Panini Classics Football

    $300
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21. 21
    
    Trey Lance [Glossy] #153 2021 Panini Classics Football

    $300
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22. 22
    
    Mac Jones [Premium Edition Significant Signature Green] #156 2021 Panini Classics Football

    $300· $300 new/sealed
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23. 23
    
    Micah Parsons [Premium Edition Significant Signature Gold] #196 2021 Panini Classics Football

    $294.9· $202.5 new/sealed
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24. 24
    
    Justin Herbert [Timeless Tributes Purple] #99 2021 Panini Classics Football

    $260.85· $55.5 new/sealed
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25. 25
    
    Micah Parsons [Premium Edition Significant Signature Green] #196 2021 Panini Classics Football

    $260.74
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26. 26
    
    Trevor Lawrence [Premium Edition Significant Signature Gold] #151 2021 Panini Classics Football

    $258.96· $250 new/sealed
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27. 27
    
    Justin Fields [Premium Edition Significant Signature Green] #154 2021 Panini Classics Football

    $251.26· $565 new/sealed
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28. 28
    
    Tua Tagovailoa [Premium Edition Significant Signature Gold] #67 2021 Panini Classics Football

    $250
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29. 29
    
    Aaron Rodgers [Premium Edition Significant Signature Gold] #38 2021 Panini Classics Football

    $250
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30. 30
    
    Emmitt Smith [Premium Edition Significant Signature Green] #127 2021 Panini Classics Football

    $249.95
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31. 31
    
    Mac Jones [Premium Edition Timeless Tributes Orange] #156 2021 Panini Classics Football

    $243.5· $29.99 new/sealed
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32. 32
    
    Ja'Marr Chase [Premium Edition Significant Signature Green] #157 2021 Panini Classics Football

    $240· $290 new/sealed
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33. 33
    
    Justin Herbert [Premium Edition Significant Signature Green] #99 2021 Panini Classics Football

    $232.94
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34. 34
    
    Russell Wilson [Premium Edition Significant Signature Blue] #85 2021 Panini Classics Football

    $224.95· $199.99 new/sealed
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35. 35
    
    Ezekiel Elliott [Premium Edition Significant Signature Gold] #53 2021 Panini Classics Football

    $219.99
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36. 36
    
    Jalen Hurts [Premium Edition Significant Signature Orange] #57 2021 Panini Classics Football

    $211.52· $211.52 new/sealed
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37. 37
    
    Trevor Lawrence [Premium Edition Significant Signature Green] #151 2021 Panini Classics Football

    $210· $260 new/sealed
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38. 38
    
    Davis Mills [Premium Edition Significant Signature Blue] #172 2021 Panini Classics Football

    $205.5· $26 new/sealed
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39. 39
    
    Ja'Marr Chase [Premium Edition Significant Signature H2 Purple] #157 2021 Panini Classics Football

    $202.5
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40. 40
    
    Trevor Lawrence [Premium Edition Significant Signature H2 Purple] #151 2021 Panini Classics Football

    $200.5· $250 new/sealed
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41. 41
    
    Josh Jacobs [Premium Edition Significant Signature] #97 2021 Panini Classics Football

    $200
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42. 42
    
    Justin Fields [Timeless Tributes Blue] #154 2021 Panini Classics Football

    $200
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43. 43
    
    Taysom Hill [Premium Edition Significant Signature] #14 2021 Panini Classics Football

    $200
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44. 44
    
    T. J. Watt [Premium Edition Significant Signature Blue] #37 2021 Panini Classics Football

    $200
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45. 45
    
    Derek Carr [Premium Edition Significant Signature Gold] #96 2021 Panini Classics Football

    $200
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46. 46
    
    Bo Jackson [Premium Edition Significant Signature Blue] #112 2021 Panini Classics Football

    $200· $200 new/sealed
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47. 47
    
    Aaron Rodgers [Timeless Tributes Blue] #38 2021 Panini Classics Football

    $199
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48. 48
    
    Aaron Rodgers [Premium Edition Significant Signature Orange] #38 2021 Panini Classics Football

    $193
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49. 49
    
    Justin Fields [Premium Edition Significant Signature] #154 2021 Panini Classics Football

    $190.5· $200.5 new/sealed
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50. 50
    
    Steve Young [Premium Edition Significant Signature Gold] #115 2021 Panini Classics Football

    $184.26· $184.26 new/sealed
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Values are informational estimates from real sales data. JunkPal may earn a commission when you buy through eBay links, at no extra cost to you.