# The Most Valuable 2025 Panini Origins Football Cards

The current peak in the 2025 Panini Origins market is driven by elite athlete scarcity and high-demand autograph combinations. Patrick Mahomes II [Black Autograph] #49 is commanding a price of $4049, while Tetairoa McMillan [Holo Black] #116 sits at $2500. Value in this segment is primarily dictated by the intersection of player profile, card rarity, and verified condition. This ranking reflects real-time market activity, continuously updating based on live eBay sold comparable prices.

**1614 items ranked** by median closed-sale value.

The ranked list with current values is on the page: [https://junkpal.ai/best/most-valuable-2025-panini-origins-football-cards](https://junkpal.ai/best/most-valuable-2025-panini-origins-football-cards)

- [Sold listings on eBay](https://junkpal.ai/api/go?to=https%3A%2F%2Fwww.ebay.com%2Fsch%2Fi.html%3F_nkw%3DThe%2520Most%2520Valuable%25202025%2520Panini%2520Origins%2520Football%2520Cards%26LH_Sold%3D1%26LH_Complete%3D1%26mkcid%3D1%26mkrid%3D711-53200-19255-0%26siteid%3D0%26campid%3D5339166094%26toolid%3D10001%26mkevt%3D1%26customid%3Dmd-best-sold&p=md-best-sold)
- [Current listings on eBay](https://junkpal.ai/api/go?to=https%3A%2F%2Fwww.ebay.com%2Fsch%2Fi.html%3F_nkw%3DThe%2520Most%2520Valuable%25202025%2520Panini%2520Origins%2520Football%2520Cards%26mkcid%3D1%26mkrid%3D711-53200-19255-0%26siteid%3D0%26campid%3D5339166094%26toolid%3D10001%26mkevt%3D1%26customid%3Dmd-best-live&p=md-best-live)

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_Updated 2026-09-14._

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Source: [https://junkpal.ai/best/most-valuable-2025-panini-origins-football-cards](https://junkpal.ai/best/most-valuable-2025-panini-origins-football-cards) · JunkPal price guide (junkpal.ai)
Values are medians of real closed eBay sales — estimates for reference, not offers or appraisals.
More machine-readable surfaces: [/llms.txt](https://junkpal.ai/llms.txt)